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Using the GCRLE grant, Munakata and Namekawa will seem extra closely at how oocytes are genomically primed and saved for afterwards use. They're going to examine the job of a chromatin remodeler in oocyte survival and fertility.

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Namekawa thinks that in human oocytes, alterations in these designs could disrupt the delicate choreography of genes becoming turned on and off at the appropriate situations — leaving them unprepared for fertilization or progress into healthier embryos. Alterations in chromatin construction being an oocyte ages might also effects the way that chromosomes segregate in the course of mobile division.

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